The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder

The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder

Discussion: Angela is a 54-year-old married woman with three adult children. She has been the office manager of a small law firm for 20 years and has enjoyed her work until this past year. She has rheumatoid arthritis with minimal impairment that has been managed well with NSAIDs. She has been taking conjugated estrogens for 8 years and decided to stop taking them because of her concern of their risks without sufficient medical benefit. She has tolerated the discontinuation without difficulty. Assessment: At her annual medical checkup appointment, she told her primary care provider that she seemed to be tired all the time, and she was gaining weight because she had no interest in her usual exercise activities and had been overeating, not from appetite but out of boredom. She denied that she and her husband have had marital difficulties beyond the ordinary and she was pleased with the achievements of her children. She noticed that she has difficulty falling asleep at night and awakens around 4 a.m. most mornings without her alarm and cannot go back to sleep even though she still feels tired. She finds little joy in her life but cannot pinpoint any particular concern. Although she denies suicidal feelings, she does not feel that there is meaning to her life: “My husband and kids would go on fine if I died and probably wouldn’t miss me that much.” The primary care provider asks Angela to fill out a Beck’s Depression Scale, which indicated she has moderate depression. 1. What medication would you first prescribe to this patient? 2. She comes back in 2 weeks and states she has not noticed and change in her mood since starting on the medication. What would be your response? 3. What are the possible problems with the medication you prescribed? 4. How long should you continue the treatment regimen? Rubrics Quality of Initial posting- The information provided is accurate, providing an in-depth, well thought-out understanding of the topic(s) covered. An in-depth understanding provides an analysis of the information, synthesizing what is learned from the course/assigned readings. Writing Mechanics- Minor to no errors exist in grammar, mechanics, or spelling in both the initial post and comments to others. Formatting of citations and references is correct. If required for the assignment, utilizes sources to support work for both the initial post and the comments to other students. Sources include course and text readings as well as outside sources (when relevant) that are academic and authoritative (e.g., journal articles, other text books, .gov Web sites, professional organization Web sites, cases, statutes, or administrative rules).